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Importantly, tumour cells actually depend on activated Akt for survival whereas normal cells do not [ 23].
The differential influence of versican G3 on breast cancer cells and osteoblasts may depend on activated expression of EGFR signaling and its downstream pathways.
Previous studies have shown that proliferation and survival of 3 of these (BxPC-3, HS766T and L3.6sl) depend on activated Wnt signaling [M. Pasca di Magliano and M. Hebrok, unpublished observations].
Gliomas seem to depend on activated STAT3: inhibition of STAT3 is known to suppress proliferation [ 34], and STAT3 knockdown reportedly induces apoptosis in glioma cells [ 35].
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ADCC and ADCP depend on activating Fc receptors FcγRI, FcγRIII, or FcγRIV in mouse and on FcγRI, FcγRIIA, FcγRIIC, and FcγRIIIB in human (Nimmerjahn & Ravetch, 2006; Bruhns, 2012).
Thus, differences in susceptibility to NK-92 cell-mediated lysis depend on activating receptors, e.g., NCR and NKG2D (afferent resistance), or on resistance to the cytolytic mechanisms of NK cells, e.g., perforin, granzymes, and Fas-ligand (efferent resistance).
The notion of a supposed Democratic lock on the White House depends on activating the famed Obama coalition, which is heavily reliant on overwhelming strength among young voters and people of color.
Studies in Arabidopsis and rice indicated that the different SPX domain proteins interact with each other, forming a regulatory network depending on activating and inhibiting interactions [ 96, 98].
Under simplified conditions, we obtain closed form expressions of the upper and lower bounds of the collapse loads, which depend on the activated collapse mechanism.
The surface functional groups of the PVA-ACFs depend on the activating agents.
Hence, Notch signaling does not critically depend on Egfr activity to be activated or maintained.
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