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That led to some sharp departures from protocol.
Also, the effect of departures from protocol on clinical trial results can easily be evaluated by the use of simulation.
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In a remarkable departure from protocol, a key figure within the Catholic Church in England and Wales also came out publicly against Cardinal Bertone's comments.
In a departure from protocol, he told the pontiff in a special tribute: "We are deeply grateful for your strength of spirit and the apostolic courage with which you proclaim Christ's gospel".
But its unspoken reaction was frosty: No military commander attended Mr. Gul's inaugural ceremony, a highly unusual departure from protocol, considering that he is now the commander in chief.
Nonetheless, Markle's alleged remark was a departure from protocol, and the revelatory tweet, which had been made by Senator Catherine Noone, the deputy leader of the Irish opposition party, was swiftly deleted, presumably after a call from the Palace.
In a rare departure from protocol, the president, vice-president and their families turned up to greet the pontiff, underlining the huge expectations for a historic visit which will include talks at the White House and addresses to Congress, the United Nations and vast crowds in Washington, New York and Philadelphia.
After Hillsborough, officers were told to file statements on plain white paper rather than using their official notebooks – a significant departure from protocol.
As will be detailed in the analysis section, this departure from protocol necessitates particularly extensive comparison of characteristics of the (consenting) women at baseline, with suitable control for any differential selection across the trial arms.
12 In a departure from protocol and to align with the move towards limiting the number of primary outcome measures, we did not include symptom severity at the 12 month time point as a primary outcome.
Departures from the protocol during conduct of a clinical trial: a pattern from the data record consistent with a learning curve.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com