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The average population parameter values, their inter-individual variances, and the residual variance of square root CD4 count departures from a linear trajectory were drawn from the literature review.
For both males and females, we tested the combined incidence of adenoma and carcinoma for departures from a linear dose response (data not shown).
Correlation with steatosis showed that despite significant departures from a linear model fit, there was a distinct trend linking PC1 and steatosis incidence (Fig. 5C; supplementary material Table S4).
The prior for β2, E is chosen to reflect a strong belief against a quadratic relationship but allows the model flexibility should there be drastic departures from a linear relationship.
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We found no statistically significant departure from a linear association between fish consumption and RA risk (Pnon-linearity =0.15).
As tests did not suggest departure from a linear trend (P for departure from a linear trend=0.20), we used socioeconomic status as a continuous three level variable.
There was no significant departure from a linear exposure-response relationship (p>0.05).
Continuous covariates that did not display departure from a linear relationship with the outcome were entered as linear terms.
As tests did not suggest a departure from a linear trend, we used the measure of SES as a continuous 3-level variable.
Furthermore, we did not find evidence of a departure from a linear relationship between PM and BP, which supports the importance of reducing PM exposures at all levels.
With the data restricted to the lower end of cumulative exposures, below 200 WLM, there was no evidence for departure from a linear model.
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