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"depart radically" is correct and usable in written English.
It is usually used as a metaphor to refer to a sudden or dramatic change in perspective or behavior. For example, "The CEO took a radical departure from the company's usual policies when introducing the new initiative."
Exact(15)
Nobody is going to depart radically from the selling pattern except a writer of genius.
He knew practically nothing of the new plans for the interior, which depart radically from his own conception, and the news depressed him profoundly.
These new projects show no diminishment of his interest in form; neither do the forms depart radically from the modern vocabulary on which his own is based.
These tend to depart radically from both the spirit and the letter of Milne's books, and they range in quality from unbearable to adequate.
Cowell was happy to see the films by DreamWorks depart radically from the narrative and style of the 12 books in the series.
Both works depart radically from the more controlled, idealized pictures of either the Neoclassical or the Romantic school; they portray the life and emotions not of aristocrats but of humble peasants, and they do so with a realistic urgency.
Similar(45)
It would be odd if curricula departed radically from the academic consensus.
If the current president departs radically from that pattern, it will be a surprise.
The New Pathway departs radically from the traditional approach to medical education.
In one way, however, it departs radically from reality: no one criticizes the boss.
This is a modem development, departing radically from the constitutional practice of the first 150 years of the Republic.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com