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At later time points the model also exhibits features characteristics of late-stage human OA including denudation, and osteophytes and fibrocartilage-like tissue are present at the denuded surface when FM is applied [ 60, 63].
Here we show that transient, physiological hypoxia occurs in the menstrual endometrium to stabilise hypoxia inducible factor 1 (HIF-1) and drive repair of the denuded surface.
Similar to effects in the mouse model of colitis44, the actions of DMOG in the endometrium appear to be secondary to improved epithelial function, with reepithelialisation of the denuded surface a major contribution to the improved histological repair scores.
It has been hypothesized that mucosectomy causes ischemic damage, but no direct histological evidence has been found and attention is now focused on the urothelium cover to prevent the exposure of the denuded surface to urine or the use of balloons to keep the flaps distended.
The breast defect (c) was repaired and filled with the FDFG, with the denuded surface fitted to the pectoralis major muscle (d).
The high-velocity jet stream created by blood passing through a defect in the aneurysm may allow platelets and fibrin to adhere to the partially denuded surface of endothelium, creating a sterile thrombus, though it can potentially host microorganisms [30].
Similar(45)
It should be pliable enough to mold itself to the joint surfaces and cover all denuded surfaces.
It can probably be performed with success in younger children than can the astragalo-scaphoid arthrodesis, because the layers of cartilage are thinner than in the head of the astragalus, at equal ages, and it is therefore easier to obtain approximation and union of the denuded surfaces.
The denuded endothelial surface was determined in each group.
In studying the role of hypoxia and HIF-1 at menstruation using human endometrial tissue and mouse models of simulated menses, we reveal hypoxia stabilises HIF-1α in the menstrual endometrium to enable timely repair of the denuded endometrial surface.
Recently, many cases of medication-induced osteonecrosis of the jaw have been reported, and these patients have denuded bone surface [9].
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