There was no difference in terms of neovascularization, while the density of the collagen stroma and ingrowth of connective tissue were increased.
We assessed the fraction area for components of endometrium and myometrium and VV (volume density) and SV (surface density) of the gland and stroma using the M36 test system provided by the STEPanizer Stereological Tool.
These data are in agreement with our qualitative observations that used immunofluorescence to document the relative density of the tumor and stroma cell populations in the MAM-1 co-cultures (Fig. 6B).
Studying the case of one particular graft usually led to observations that were in accordance with the intuitively expected behavior: when the cornea swells, the TIS value increases, as does the density of the lakes within the stroma.
However, no significant correlation was found between the increase of the keratocyte density of posterior stroma layer with SIA.
Patients with a high density of lymphocytes in the stroma of tumors, for instance, had a better clinical outcome compared to patients with a low density of lymphocytic infiltration of tumor stroma.
Noteworthy, m Cd31 and m Cd105 expression levels were highly correlated with the proportion of mouse cells (Table 2), suggesting that the relative amount of endothelial cells remains stable within diverse stromal cell populations, whatever the density of stroma component and the cancer type.
The keratocyte density of posterior stroma layer was increased significantly at 1 week, 2 weeks, 1 month, 3 months postoperatively (p < 0.05, Additional file 1), but not statistically significant (p = 0.173, Additional file 1) at 6 months postoperatively.
When the three components of synovitis score (hyperplasia of intima, cellular density of synovial stroma and inflammatory cell infiltration) were subanalyzed, the inflammatory cell infiltration was found to correlate best with synovial TRAF6 expression (r = 0.367, P = 0.014) (Table 2 and Figure 4B-D).
