Sentence examples for density of origins from inspiring English sources

As discussed above, this is a far lower density of origins than seen in other eukaryotes.

This rapid replicative cycle would require each of the three rounds of DNA replication to take place over a 3 5 minute window, which, assuming a processivity of the order of 1-2kbp/min for eukaryotic replication [ 60], would require an exceptionally high density of origins of replication throughout the genome.

Extrapolating to the whole megabase chromosome genome, we predict a total of ∼100 origins, giving an origin density of 1 origin per ∼260 Kbp, significantly sparser than budding yeast (1 origin per 46 Kbp) (Yabuki et al., 2002), Arabidopsis (1 origin per 77 Kbp) (Costas et al., 2011), or mammals (1 origin per 25 Kbp–1 origin per 130 Kbp) (Sequeira-Mendes et al., 2009; Cayrou et al., 2011).

Therefore, the precocious replication of the GC-rich chromosomal arm during S-phase is not due to a higher density of replication origins nor to a peculiar distribution of origin positions along the chromosome.

First, and most strikingly, the peaks observed are broad and well spaced, indicating a low density of active origins.

Replication defects at fragile sites may be a consequence of a low density of licensed origins or it may reflect inefficient or delayed initiation of replication forks.

The study was conducted in the North-West of England, in areas with high density of Pakistani-origin population.

With a complete set of 252 replication origins, there is an average density of about one origin every 45 kb in the genome.

Both studies show that the density of usable replication origins is a key determinant of genome stability in S phase.

Despite a general positive correlation of early replication with the high density and frequency of the usage of origins, the EtoL replication domains had even slightly lower origin scores when they were early replicating than when late replicating [ 80].

Note that reduced D2-receptor availability––as measured by [11C]-raclopride PET can have three possible origins: reduced density of post-synaptic D2-receptors, increased levels of synaptic dopamine or both.