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Treatment with CDDO reduced the density of lymphocytes in spleen and significantly diminished lymphocyte infiltration in lungs.
Sale and colleagues described a comparable feature with "focal increase in density of lymphocytes, plasma cells, and occasional eosinophils in the LP" [ 13].
Patients with a high density of lymphocytes in the stroma of tumors, for instance, had a better clinical outcome compared to patients with a low density of lymphocytic infiltration of tumor stroma.
Lymphoid depletion was classified by the density of lymphocytes and scored as 0 = no reduction, 1 = reduction up to 30%, 2 = reduction up to 50%, 3 = reduction up to 90%, respectively.
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A strong association has been reported between HER-2, c- myc and int-2 oncogene amplification in breast tumour samples and the density of lymphocyte infiltration of the tumour [ 22].
From these figures, the densities of lymphocytes per mm were calculated using the TMA core area as reference [ 20].
Although it is difficult to extrapolate from in vitro to in vivo situations, the lack of a cytotoxic effect due to the presence of Kyn at a low concentration in the tumor microenvironment could explain previous observations of high densities of lymphocytes in NPC tumor tissue.
The presence of trypanosomes is usually only seen indirectly, by the movements of the lymphocytes, because the great density of the lymphocytes will obscure the trypanosomes.
The densities of CD4+ T lymphocytes, CD8+ T lymphocytes, and macrophages was quite strong, positively linked to each other, whereas the density of B lymphocytes, NK cells, and mast cells seemed to be independent.
Moreover, there was an apparent reduction in the density of T lymphocytes remaining on the surface of the PCgel as compared that on the surface of Matrigel, suggesting that T lymphocytes were more effective in infiltrating the PCgel than Matrigels.
The density of T lymphocytes were adjusted to 2 × 10 cells/mL in regular medium without FBS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com