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One of the interesting findings of this work is that genes with higher density of conservation and active regulatory marks but not repressive marks in first introns tend to have more exons that encode longer proteins, which can be interpreted to suggest that long functionally complex proteins may also be under a richer regulatory control.
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"If you have a big area of conserved forest you will probably end up with increased density because of conservation alone, because when the forest is not utilised for wood then the trees can grow and become bigger," said Mr Rautiainen.
Differences between the wood density of the conservation areas and the two different sampling protocols were tested with a one-way ANOVA and a multiple comparisons procedure using the grouping variables conservation area and sampling protocol.
Both sites of homology corresponded to regions of high LINE/SINE density suggesting conservation of repetitive elements may account for the sequence homology, rather than any regulatory or control regions.
Additionally, trends in the density of large trees per conservation area match trends in EAGB per conservation area.
An existing set of finite-difference formulae for incompressible flow is generalized to handle arbitrary large density fluctuations with no violation of conservation through the non-linear convective terms.
The hydrodynamic equations have the form of a Euler-like system of conservation laws for density, n, momentum, u, and energy, e, in each of the two bands (the band indices are here omitted).
However, the height of the tree reflects only the density of hits not the quality of conservation within.
The analyses described above identified 2 kb sequence windows upstream of Olig2 that either contained a high density of potential TFBS, showed high conservation across many vertebrate genomes, or showed stretches of perfect HMR conservation.
The identification of a correlation between microsynteny conservation and density of disease gene orthologs suggests that additional experimental analysis of mouse genes in highly conserved genomic regions will produce new mammalian disease models by creating mutations in the orthologs of human disease genes.
Interestingly, it was predicted to be functional in a recent in silico study based on sequence conservation and density of potential transcription factor binding sites [29].
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