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In the second step, the NCAPG specific network was extracted for genes that most densely interact with each other by using the MCODE software.
HK TFs tend to have neighbours that densely interact with each other, indicating that HK TFs are inclined to form complicated associations with other TFs and miRNAs in the expression of genes.
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One solution is to decompose such an interaction network into communities of densely interacting nodes and imply functional modules.
To further elucidate this relationship, the present study established a gene-gene interaction network comprising NCAPG and its densely interacting genes from the growth network.
To address such limitations, we adopted a mixture modeling procedure to construct a probabilistic genetic interaction network and then implemented a Bayesian approach to identify densely interacting modules in the probabilistic network.
One approach to analyze EMAP data is to identify gene modules with densely interacting genes.
We propose to use contact residues that are densely interacted in a compact region to model a hot spot.
The key difference from these existing work is that we investigate clusters of contact residues that are densely interacted like a biclique in a compact region where the compactness is measured by the water exclusion principle.
Especially in scenarios, where fast, densely packed particles interact, challenges arise for classical methods like Particle-in-Cell or Monte-Carlo.
In skin, sunlight and allergen induced inflammations cause keratinocyte signalling molecules [195] to interact with densely interwoven epidermal [196] L-DC.
The combination of the three significant factors reveals the importance for the presence of rinderpest of local neighbourhood and geographic compactness interacting in densely populated areas, an effect that has been reported before for human diseases such as STDs and HIV-AIDS [ 35, 6].
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