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A less dense treatment of the legal issues may be found in Bruce Bell's " The Coming Storm".
For the dense treatment, four plants surrounded each plant in a 6-inch square pot; for the nondense treatment, a single plant was grown per 6-inch pot.
G-CSF to facilitate dose dense chemotherapy (two vs three weekly CHOP) in the first-line therapy of aggressive NHL (Pfreundschuh et al, 2004a, 2004b) improved 5-year event-free and overall survivals without any significant increase in the incidence of second cancers in the dose dense treatment arms after 58 months median follow-up.
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For greenhouse sample collection, both genotypes were germinated and grown as indicated above, and 10 d after germination the seedlings were transferred to a greenhouse, transplanted to soil, and subjected to nondense and dense treatments.
CONCLUSIONS: This dose-dense treatment regimen is active, feasible, and tolerable.
Dose-dense treatment, and timely treatment did not have a significant effect on 24-month PFS.
There was no significant advantage to dose-dense treatment for patients with optimally cytoreduced disease.
Dose-dense treatment was associated with improved DFS and OS, with no increase in toxicity.
Dose-dense treatment is defined by delivery of a maintained per-cycle dose or overall dose with administration of drug at shorter time intervals than is standard.
The substantial DFS achieved supports the use of dose-dense treatment is worth ensuing also when age and cardiac comorbidity increase the complexity of lymphoma management and may affect survival (Aapro et al, 2010).
Therefore, our regimen could probably be easily administered with a 3-weekly schedule; otherwise, using a biweekly schedule in order to keep a dose-dense treatment, a substantial reduction of all cytotoxic drugs seems advisable.
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