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Most prominently, the amygdala receives dense input from the prefrontal cortex, especially from the anterior cingulate and orbitofrontal cortices.
Mo5 receives glutamatergic projections predominantly from the parvocellular reticular nucleus (PCRt) but also a less dense input from the paramedian reticular area (PMnR) [7], [15].
On the one hand, it is based on a focal and dense input to a compact dendritic compartment, as has been quantified for L4 spiny stellate neurons.
The mammillary nuclei in general receive dense input from the hippocampus [reviewed in [ 103]], and lesion studies suggest a role for the LM in spatial learning and memory in rats [ 104].
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Although the lateral mammillary nucleus receives dense inputs from Gudden's dorsal tegmental nucleus, the VTNg was targeted because of its inputs to the medial mammillary nucleus.
The mammillary bodies receive dense inputs from Gudden's tegmental nuclei (e.g., Takeuchi et al., 1985), making it possible that these midbrain inputs are functionally important for memory (Vann, 2010).
Furthermore, in view of evidence that the human retrosplenial cortex is important for episodic memory (Valenstein et al., 1987; Maguire, 2001; Vann et al., 2009), particular significance may be attached to the very dense inputs from areas 29 and 30 to both the anterior ventral and laterodorsal nuclei.
Through our continued collaboration with Menno Witter, it became possible, for the first time, to target electrodes to the exact part of entorhinal cortex that provides the densest input to the place cells in CA1 of the dorsal hippocampus.
Stepniewska et al. [ 74, 75], Greenlee et al., [ 76] and Dum and Strick [ 77] have shown that the densest inputs from premotor areas to the orofacial and digit representation in primary motor cortex originate from dorsal and ventral premotor areas.
Using targeted injections of horseradish peroxidase, Henderson (1987b) reported that the densest inputs to the ferret visual cortex arise in the most posterior regions of the NB, similar to the pattern of cholinergic innervation observed in the primate striate cortex (Mesulam et al., 1983).
In cerebellum after HCA, D-FITC is prominent in many Purkinje cells (PC), which receive dense glutamatergic input and are often injured, and surrounding small hemorrhages.
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