Actively recruiting trials (e.g. trials of the AGO PREPARE and TECHNO) integrate modern concepts of treatment like dose-dense, dose-intensified, sequential therapy and tumor targeting with trastuzumab in PST.
The Preoperative Epirubicin Paclitaxel Aranesp (PREPARE) study evaluated the effect of preoperative dose-dense, dose-intensified chemotherapy with anthracyclines and taxanes in breast cancer patients (N=733).
NCR01378533 is an adjuvant phase III trial comparing a dose dense anthracycline taxane regimen to dose dense paclitaxel and carboplatin.
Compared with the historical controls, dose dense and intense induction chemotherapy decreased distant failure rate without compromising the locoregional control.
OBJECTIVE: To perform a phase II trial evaluating dose dense induction chemotherapy for locally advanced head and neck cancer.
This complication seemed wholly attributable to the dose dense FEC.
Dose dense showed a trend for improved disease-free survival (DFS) and overall survival (OS).
Instead, the sequential (more dose dense) plan was associated with significantly improved DFS and OS.
Dose dense schedule is widely used as an AC-T schedule unless there are other factors.
