Exact(1)
Pores previously present in the nascent, thin biofilm, which might have been filled by clonal expansion of either population, are filled entirely by blue cells which form a dense basement layer in the biofilm (Fig. 2A, B).
Similar(59)
Arrowheads electron-dense bArrowheads electron-denseMTJs.
In contrast to our results, a previous analysis [55] demonstrated much higher efficiencies (10 65%) for autocrine capture; however, these probabilities would only arise if the interstitial space were as structurally dense as basement membranes and VEGF diffusivities were as low as 0.1 1 µm2/s [54].
ECM degradation is likely to be particularly critical for invasion of epithelial tumors surrounded by dense crosslinked basement membranes, since they cannot be traversed without proteolytic activity (Parekh and Weaver, 2009).
Electron microscopy of brain arterioles revealed characteristic electron dense deposits within the basement membrane (Fig. 2d) reminiscent of GOM deposits seen in CADASIL patients (Fig. 2e).
The simulations suggested that dense matrix (such as basement membrane) forms an effective barrier to prevent invadopodia penetration and matrix degradation, whereas looser matrices (such as stroma) have gaps sufficient to allow invadopodia penetration and matrix degradation.
Transmission electron microscopy demonstrates the deposition of non-fibrillar, powdery, electron dense deposits along the tubular basement membrane, glomerular basement membrane and blood vessels.
Electron microscopy demonstrated mesangial and subendothelial glomerular basement membrane electron-dense deposits without dense transformation of the glomerular basement membrane.
Investigation by means of fluorescence microscopy and spectroscopy reveals that QD diffusion in the dermis is limited by the basement membrane and dense connective tissue fibers, resulting in negligible QD penetration to the epidermis, hair follicles, sebaceous and sweat glands, nerves, and blood vessels.
These fragments are observed as electron dense structures (EDS) along glomerular basement membranes (GBM) and in the mesangial matrix.
DDD is diagnosed by renal biopsy, which shows dense transformation of the glomerular basement membrane, often with MPGN.
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