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Last year, Christian Smith released "Tronic Treatment" (Moonshine), a well-constructed CD that showed off his dense approach to mixing.
Analysis of our data strongly suggests that this dose dense approach may be superior only in some subsets of patients and not in the whole population.
Because of the availability of hematopoietic growth factors to reduce granulocytopenia and risk for infections, the 'dose dense' approach could be evaluated in a series of pilot adjuvant trials at Memorial Sloan-Kettering Cancer Center [ 16- 18], with promising results.
Although our dose dense approach did not cause any life-threatening toxicity, it produced a substantial increase of severe side effects, which may negatively impact on the quality of life of patients.
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As a conclusion, amongst the few existing one-to-one HTs, none is a dense method, and none of the existing dense approaches is a one-to-one projection.
Furthermore, platinum resistant patients with existing peripheral neuropathy or other co-morbidities such as diabetes mellitus are poor candidates for dose dense approaches that utilise either cisplatin or paclitaxel because of the risk of further deterioration of their neurological symptoms.
However, such a dose-dense approach is not recommended in women with ER/PgR positive LABC.
However, benefits of dose-dense approach must be seen in the context of greater non-haematological toxic effects, myelosuppression being no longer the limiting toxicity.
In younger patients dose-dense adjuvant chemotherapy regimens are often used, however, in the pivotal CALGB 9741 trial demonstrating the benefits of the dose-dense approach only 3% of patients were aged 70 or over (Citron et al, 2003).
An important part of the discussion on new chemotherapy strategies included the dose-dense approach, a strategy believed to offer the chance of overcoming tumor re-growth between consecutive cycles.
This relative failure of a single high-dose therapy we believe opens up the development of a dose-dense approach with block scheduling as the most promising way forward.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com