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FD then corresponds to the total dendrogram branch lengths connecting community members together.
The right dendrogram branch is not composed of one predominant subtype as was seen for the left cluster, and contained a mix of Luminal, HER2+, and Normal-like samples (Table 4).
The HER2+ intrinsic subtype (pink dendrogram branch in Figure 2B) was predominantly ER-negative (i.e. HER2+/ER-) as previously shown.
However, the primary dendrogram branch for 5FU-treated basal-like cell lines also included two early time points for DOX-treated ME16C.
In the case of consistently regulated spots (b), these similarities become even more pronounced as can be deduced from the dendrogram branch lengths.
Additional analysis revealed that the orders between iMR1_799, iMR4_812, and iW3181_789 can switch with just a few changes in the genes considered due to the small differences in the dendrogram branch heights.
Similar(52)
Statistically significant dendrogram branches (*, p≤0.001) were determined with SigClust [18].
The resulting value of 88% cluster similarity was used to abridge dendrogram branches above this similarity value.
The variability between the brain regions (measured by the height of the dendrogram branches) is considerably larger than the variability within the regions.
The basal-A subtype (red dendrogram branches) contained many of the "HCC" lines established at UT Southwestern, including two known BRCA1 mutant lines (HCC1937, HCC3153) ([34], and this study).
The basal-B subtype (orange dendrogram branches) included non-tumorigenic lines (MCF10A, hTERT-HME1, 184A1) as well as several highly invasive lines exhibiting features of epithelial-mesenchymal transition (EMT) (MDA-MB231, MDA-MB436, MDA-MB157, Hs578t) [36].
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