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Demonstrations of increased hyperactive locomotor responses, lower triglyceride levels, increased hunger-driven feeding behaviors, higher metabolic rates, and lipid accumulation phenotypes in liver-like oenocytes indicate that the loss of AMPK leads to a persistent starvation signal both at the organismal and cellular levels.
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To the best of our knowledge, this is the first demonstration of increased [11C]erlotinib uptake in NSCLC tumors harboring the L858R point mutation.
The clinical suspicion of FA is confirmed by the demonstration of increased spontaneous and induced chromosome breakage, excessive accumulation of cells in the G2 phase of the cell cycle, or targeted DNA sequencing.
Wang and colleagues further elaborated this concept by demonstration of increased Urokinase-type plasminogen activator receptor (uPAR) expression, in the small airway epithelium of patients with COPD, participating in an active EMT process [22].
This was confirmed by the direct demonstration of increased apoptosis, which was accompanied by increased proliferation.
These findings are reinforced by the recent demonstration of increased Ang II synthesis in cardiac myocytes from diabetic rats.
However, the demonstration of increased Etr1/Mecr in Mecr transgenic hearts failed based on both immunoblot analysis and enzyme activity assays, for discussion, see below.
Our previous demonstration of increased angiogenesis in animals with genetic disruption of (the glucocorticoid-generating enzyme) 11β-HSD1 (7) suggest that these in vitro data obtained with concentrations of cortisol approaching high physiological levels are relevant in vivo.
Intact uptake of 125I-Ang(1 12) was significantly higher in SHR, a finding that agrees with the previous demonstration of increased Ang-(1 12) content in the myocardium of adult hypertensive rats by both immunohistochemistry and RIA.
Correct cannula placement was confirmed by demonstration of increased drinking after i.c.v.
The diagnosis of bacterial overgrowth is determined by aspiration of the jejunum and demonstration of increased bacterial contents by culture.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com