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The primate studies described in this chapter complement a wide range of rodent studies with demonstrations of functional recovery and anatomical connectivity that extend the knowledge of the restorative capacity of striatal tissue transplants.
However, there have been fewer direct demonstrations of functional activities of hESC-derived neuronal cells.
Soon after the first demonstrations of functional expression of the gene encoding avGFP in organisms other than jellyfish [ 3, 4], published reports of the use of fluorescent proteins (FPs) for microscopy applications 'took off' [ 5].
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This is the first demonstration of functional epithelia outside of the Eumetazoa sensu stricto.
Functional studies of the mitochondrial sdh4 gene, or demonstration of functional transfer of sdh4 to the nuclear genome, will help resolve these possibilities.
In addition, this is the first demonstration of functional neural cell types derived from canine fetal brains, a potential resource for future studies on canine CNS disease physiology.
The first novel aspect of the work presented here is the identification of the interaction between HLA-DRα2 and TIRC7, and the demonstration of functional relevance of this binding.
This view has recently changed dramatically with the demonstration of functional BAT in adult humans [15] [19] adding to the observation of brown-like multilocular adipocytes expressing UCP1 interspersed within human WAT [20] [22].
The demonstration of functional GABAA responses in human unmyelinated axons supplements the body of work showing that GABAA receptors are functionally expressed in axons in the mammalian peripheral and central nervous system [1], [13], [28] and may have implications for the pathogenesis of some forms of neuropathy.
More importantly, this was the first demonstration of functional vascular effects of roxarsone that may implicate a disease risk.
Disrupted expression and trafficking of the vt21 mutant provides the first demonstration of functional relevance in vivo of a highly conserved, structural feature of SLC6 transporters.
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CEO of Professional Science Editing for Scientists @ prosciediting.com