They may be applied for early diagnosis, assessment of progression and demonstration of treatment effects, particularly for disease-modifying treatments in Alzheimer's dementia.
For a clinical demonstration, the treatment records are presented for one of the participants enrolled in this study (Fig. 5).
All of these might have the potential to affect the demonstration of treatment effect.
These findings are emphasised with a demonstration of treatment effect on pro-inflammatory gene expression simultaneously (Wald statistic).
In intensive care medicine it is well known that the heterogeneity of the patient population frequently impairs demonstration of treatment effects.
Second, our results, to our knowledge, are the first demonstration that treatment effects are maintained at follow up, after the families had returned to their homes.
This suggestion was confirmed by our group with the demonstration that treatment of cultured breast cancer cells with bisphosphonates leads to growth inhibition and induction of apoptosis [ 23].
This review examines the use of PROs as both primary and nonprimary endpoints in support of demonstration of treatment benefit of new molecular entities (NMEs) and biologic license applications (BLAs) in the United States in the years 2000 to 2012.
The first demonstration of treatment-associated plaque reduction in AD brain was identified upon post-mortem evaluation of an actively immunized patient [ 3].
In contrast to the public outcry and street demonstrations demanding treatment that have been observed in the case of HIV, families may not even discuss intrapartum stillbirths even though these are eminently preventable.
