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These results provide the first demonstration that the interaction of an Lgl family member with a specific effector is critical to its function in vivo.
The present study represents the first demonstration that the interaction between PCSK9 and the LDLR can be successfully disrupted using antibodies directed against PCSK9.
Based on the demonstration that the interaction between Dnmt1 and PCNA plays a crucial role into the DNA methylation inheritance, we decided to monitor and quantify the Dnmt1/PCNA interaction by proximity ligation in situ assay (P-LISA) in cells [ 14, 15].
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The demonstration that gp41 MPER interactions with IgMa allotypic determinants outside antigen binding pockets are capable of eliciting BCR-proximal activation signals makes the important link between this unusual binding and its potential impact on gp41 MPER-specific humoral responses.
Thus, to our knowledge, this is the first demonstration that TWEAK/Fn14 interaction also activates the PI3K-Akt pathway.
Our strongest evidence comes from the demonstration that knocking down Cdk5 prevents NF hyperphosphorylation and interaction with kinesin.
In summary, these observations provide a clear demonstration of the fact that the interaction of Bub3 with MELTP motifs is crucial for the kinetochore recruitment of the Bub1 Bub3 complex.
This paper describes a real-world demonstration that involves two kinds of human-robot interaction: (1) In-situ interaction between a team of robots and a firefighter, and (2) the interaction between a remote operator and the whole system from a base station.
A recent discovery that has major implications in the pathogenesis and therapy of gout is the demonstration that MSU crystals are capable of triggering IL-1β release by its interaction with a cytoplasmic complex called the 'inflammasome'inflammasome
Of particular interest is the demonstration that interactions with the cytosolic calnexin C-tail are involved in the retention of hCav3.2 in the ER, thus restricting surface expression of the channel.
4) The demonstration of the interaction between APP and LRP4 is strong and convincing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com