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This is to our knowledge the first demonstration that suppression of OSN activity is of fundamental behavioural, ecological and evolutionary significance.
Despite the practical predictiveness of Years 1 and 2 relapses, validation as an outcome still requires demonstration that suppression of these relapses translates into suppression of long-term disability.
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The results not only provide the first demonstration that partial suppression of BACE1 is effective in preventing cholinergic neurodegeneration associated with AD but also indicate that neurotoxic Aβ42 and/or C99 species are responsible for killing cholinergic neurons.
A significant finding of this work is the experimental demonstration that hierarchical suppression among many behaviors leads to the emergence of a sequence.
But the study also provided "a strong demonstration that stereotype suppression leads stereotypes to become hyperaccessible," the authors concluded.
The involvement of endocannabinoids in depolarisation induced suppression of inhibition (DSI) and the demonstration that activation of metabotropic glutamate receptors can stimulate endocannabinoid release have provided the first insights into the physiological roles of the cannabinoids.
In particular, the demonstration of PEA3-mediated suppression of the HER2 promoter has engendered the hypothesis that PEA3 might have tumor-suppressor function that could be leveraged for anticancer gene therapy [64] [66].
The provisional government was formed in reaction to Japanese suppression of the March 1st Movement, the struggle for Korean independence from Japanese rule that had begun with a proclamation of independence issued by 33 prominent Koreans on March 1 , 1919 and a number of massive demonstrations that occurred in Korea wherever the proclamation was read.
To our knowledge this represents the first demonstration of depolarization induced suppression of excitation in area CA3 of the hippocampus.
New physics in AA are essentially observed at mid-rapidity including the demonstration that high-pT suppression is a final state effect.
Up to this point demonstration of TGFβ mediated suppression of metastases was based on genetic blockade of TGFβ signaling.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com