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The demonstration that increases in ROS levels in mammary epithelial cells, caused by matrix detachment, resulted in inhibition of FAO suggested a potential mechanism whereby apoptosis induction could lead to inhibition of lipid oxidation and led us to investigate whether the increased ROS levels observed here could be responsible for the observed decrease in β-oxidation.
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A theoretical demonstration that increasing nanoparticle concentration can decrease heat transfer was shown in [19].
The demonstration that increased utrophin can reduce the muscular dystrophy in the mdx mouse has been confirmed by others [8] [11].
This is the first demonstration that increased ROS production occurs early in a mammalian model of PD prior to neuronal stress and apoptosis, and hence suggests that it has an important role in the pathogenesis of neuronal dysfunction and death.
This is the first demonstration that increased Drp1 levels induces a specific mitochondrial stress response and inhibits cytosolic protein translation.
Moreover, to the authors' knowledge, this is the first demonstration that increased plasma levels of 15-F2t-isoprostane are a risk factor for NMSC.
Our demonstration that increased infiltration of F4/80+ macrophages and CD3+ T cells in AAL caused by AD was attenuated by treatment with TMS in ApoE−/− /Cyp1b1 +/+ mice, and in ApoE−/− /Cyp1b1−/− mice fed AD suggests that CYP1B1 plays a crucial role in inflammation associated with AAL.
These studies are critical given the recent demonstration that increased expression of the endogenous calpain inhibitor calpastatin dramatically slows disease progression in JNPL3 mice (55), which may identify an effective therapeutic strategy to prevent PSD95 cleavage and block tau-mediated synaptic dysfunction.
This finding converges with previous demonstrations that increased WM load results in greater distractor interference in Stroop-like tasks [ 27, 28], which also support the controlled attention hypothesis that WM provides goal-directed control of manipulation allowing for minimal interference by goal-irrelevant distractors.
Recent examples of the latter mechanism are the demonstrations that increased expression of the coactivator AIB1 (activated in breast cancer 1; also known as SRC3) [ 26] and decreased expression of the corepressor [ 27] are associated with tamoxifen resistance in women with breast cancer.
The recognition that fatigue is a major determinant of the functional status and quality of life of cancer patients and that mild degrees of anaemia contribute to this fatigue, coupled with the demonstration that increasing haemoglobin concentrations can reduce these fatigue levels, has led to an increase in the use of rHuEPO in this setting.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com