The experimental demonstrations presented here – on-axis Hermite Gauss and Laguerre Gauss (vortex) beams, and computer-generated holograms – are a first example of nearly-arbitrary manipulation of electron beams.
To verify that Qβ replicase manufactured variant mRNA libraries can be highly effective tools for in vitro protein evolution, two basic demonstrations are presented here.
DOI: http://dx.doi.org/10.7554/eLife.04489.022 The demonstration of Cik1 Kar3 processivity presented here provides evidence that effective translocation along microtubules does not strictly require the conventional hand-over-hand walking mechanism that has been established for conventional Kinesin-1.
The specific analyses presented here for demonstration of the method further demonstrate that nonsynonymous single nucleotide variation at the active site should disrupt enzyme function and potentially induce disease in yeast.
Because the dataset from Department of Epileptology, University of Bonn, Germany [21, 22], has been widely used for performance demonstration in many studies, the evaluation presented here focused on analyzing methods with this dataset for fair comparisons [8, 12, 14, 18, 23 34].
The second important finding presented here is the demonstration that other ligands work with myostatin to control muscle growth.
The central result of the analyses presented here is the demonstration that signatures based on the differential phosphorylation of tyrosine residues exhibit robust performance at classifying cancer from normal tissue.
The synthesis is presented here as a demonstration of knowledge transfer to promote the use of evidence in HIA.
A demonstration of such a tool is presented here, built using data from the Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II) open database.
In addition to the results presented here, and the demonstration that other CTX family members, such as JAM-A, play a role in cell-cell adhesion, in vitro experiments have also suggested an epithelial cell-intrinsic requirement for GPA33 in barrier formation and junctional complex integrity (Ackerman et al., 2008).
