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· General demonstration: Our method has reversed the normal procedure of CADD with the help of systems biology.
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For the demonstration of our method, some numerical results are presented.
As demonstration of our method, a thorough experimental validation on the nominal GPS, GLONASS, Galileo and BeiDou-M constellation is proposed.
As a further demonstration of our method, we use it to augment merger trees from the Millennium simulation (mass resolution (7.08times 10^{10}{M}}hrm{M}}_{odot}) after pruning) to match the mass resolution of the Millennium-II simulation ((5.65times10^{8}{mathrm{M}}_{odot}) after pruning).
In this demonstration of our method, the prior knowledge consists of predicted miRNA gene interactions and gene gene interactions.
Furthermore, we analysed the high osmolarity glycerol (HOG) pathway in yeast to question the validity of an existing model as another realistic demonstration of our method.
As a demonstration of our method applied to real data, we used a case/control study of severe malaria from The Gambia, genotyped on the Affymetrix 500K array (data provided by the MalariaGEN consortium, www.MalariaGEN.net).
As a demonstration of how our method works, we apply our approach to genomic sequences around the Hox gene cluster and to a set of DNA-binding proteins.
The various tests we have performed resulted in a convincing demonstration of the efficiency of our method.
We thought that confirmation of this in vivo result, even with an ex vivo application of our tools would be a nice demonstration of the strengths of our method, and it also led to us discover an in vivo limitation of the current implementation of the method due to limited aqueous solubility.
We evaluate our approaches quantitatively in lab experiments and also report on the successful integration of our methods in public demonstrations at RoboCup@Home competitions in 2011 and 2012.
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