Sentence examples for demonstration of prion from inspiring English sources

It seems likely, however, that both excreta may play an important role in the horizontal transmission of CWD, given the later demonstration of prion infectivity in urine [17] and feces [16] of CWD+ deer using transgenic mouse bioassay.

In light of the serious ramifications that would follow an unequivocal demonstration of prion disease transmission to fish, it must be emphasized here that the abnormal deposition we observed in the brains of the TSE-challenged fish could possibly have resulted from pathogenic factors other than the prions they were fed.

This is, to our knowledge, the first formal demonstration of prion propagation in a non-eukaryote.

Demonstration of prion infectivity in much smaller volumes of blood may be helpful in development of conventional blood-based diagnostic testing for scrapie in sheep.

This apparent discrepancy is relevant to the recent demonstrations of prion infectivity in urine of animals carrying experimental or naturally occurring prion diseases [42] [46].

Here, we report for the first time a direct biochemical demonstration of pathological prion protein PrPTSE and of PrPTSE-associated seeding activity, the static and dynamic biochemical markers for biological prion infectivity, respectively, in skeletal muscles of CWD-infected cervids, i. e. WTD for which no clinical signs of CWD had been recognized.

This can be seen in a common manifestation of prion disease, bovine spongiform encephalopathy, or mad cow disease.

The appearance of variant Creutzfeldt-Jakob disease in humans exposed to bovine spongiform encephalopathy (BSE) (19, 20 ) and the demonstration of CWD prions in muscle (3 ) placed the human species barrier to CWD prions at the forefront of public health concerns.

Our demonstration of ClpB-dependent prion propagation in E. coli suggests that the cytoplasmic milieu in general and a molecular machine in particular are poised to support protein-based heredity in the bacterial domain of life.

This included the demonstration that the species barrier of prion infectivity could be overcome through the introduction of PRNP from the prion donor into the recipient.

To date, a definite diagnosis can only be made by neuropathological examination and demonstration of the pathological isoform of the prion protein (PrPSc) in central nervous tissues, either at biopsy or autopsy [3].