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Demonstration of efficacy of the technique and device will require further controlled trials.
Specifically, these studies are the first demonstration of efficacy and an in vitro in vivo activity relationship for 2,5,6-trisubstituted benzimidazoles.
These findings could reflect a true lack of efficacy or methodological and other aspects of these trials that compromise the demonstration of efficacy.
Demonstration of efficacy was based on reduction in migraine frequency and use of acute medication, improvement of quality of life evaluated by the Migraine Specific Questionnaire (MSQ) and the Short-Form36 (SF36).
Several agents, including anti-VEGF drugs and mTOR inhibitors, are possible options in the treatment of advanced and metastatic pRCC, following the demonstration of efficacy obtained in clinical trials including all RCC histologic subtypes.
While the later stages of the PhAT deal with the clinical validation of the therapeutic hypothesis, early preclinical experiments are essential to define a number of the PhAT parameters, including identification of biomarkers and early demonstration of efficacy and proof of mechanism.
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But overall results aren't averaged by the FDA, who are only checking for several positive demonstrations of efficacy.
Perhaps the most important contribution that the HDSS sites can make is in the area of the implementation of interventions in 'real' settings where contextual factors have a strong influence on results, moving from demonstrations of efficacy to evidence of effectiveness.
When given in an intermittent schedule (dosing interval >2 months), oral ibandronate also provides significant vertebral antifracture efficacy (relative risk reduction 50%, p=0.0006 versus placebo), which represents the first prospective demonstration of antifracture efficacy with a bisphosphonate administered less frequently than daily (Chesnut et al 2004).
During his army service in India, he participated in an early demonstration of the efficacy of penicillin.
The high point of this otherwise misguided film is a dinner at which the Inquisition's use of torture is coolly debated — with obvious echoes of Abu Ghraib — by Inés's father and Brother Lorenzo, leading to a highly illuminating demonstration of its efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com