Sentence examples for demonstration of dose from inspiring English sources

It is also possible that the toxicity of sunitinib may have limited the ability to demonstrate dose response, though this contradicts demonstration of dose response within studies (Abrams et al., 2003; Amino et al., 2006; Ko et al., 2010).

Demonstration of dose-response relationships between chemical exposure and disease provides the most compelling evidence for a chemical etiology of illness in exposed populations.

Recent [ 11, 12] demonstrations of dose-response effects of hemofiltration in human acute renal failure and sepsis make indexing Quf to body weight a critical parameter to assess or control.

The information gained from MSM analysis of flexible dose trials may not be adequate for conclusive demonstration of the dose relationship for a medication, but may be useful to assess the need for definitive fixed dose trials of a medication and to determine the best design of confirmatory fixed-dose studies.

In addition, the previously inconclusive effects on plasma lipid of bambuterol were shown in long term studies without a demonstration of a dose relationship.

In addition, the demonstration of a dose response to psoriasis disease severity is suggestive of a direct relationship between psoriasis and risk of DM, and inflammation is likely to be a shared causal mechanism.

However, the demonstration of a dose-response effect on disease progression and disease severity is suggestive of a causal link [25], [26].

Critical to the success of gene therapy is the demonstration of efficacy at doses of vector that are safe and can be easily manufactured.

As a first demonstration of the technique, dose-dependent FRET decreases of about 20% (Y/C emission) after 2 h of treatment with trichostatin A (TSA), a deacetylase inhibitor, were observed for the K5/K8 and K12 reporters.

Safety and efficacy findings of the highest dose were particularly critical since demonstration of improved cure rates at higher doses might be critical in designing higher-dose regimens for widespread deployment.

Given a relatively favorable toxicity profile, early dose finding studies of endocrine therapy with novel agents should aim to identify the biologically effective dose as defined by demonstration of target inhibition rather than the maximum tolerated dose.