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This is the first demonstration of developmental compartments in an internal tubular organ.
This is the first demonstration of developmental compartments in a branched organ, and it will be interesting to find out whether other branched organs are also organized in a similar manner.
Nevertheless, our findings provide the first demonstration of developmental change of chromatophore photosensitivity of migratory species as well as developmental changes in the expression of two non-visual pigments, cryptochrome and melanopsin, which could participate in the photoresponses of extraretinal photoreceptors.
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In one of the recent demonstrations of "developmental tissue engineering" [ 76], Scotti et al. were able to produce a bone organ with functioning bone marrow by putting the human mesenchymal stem cells through an endochondral bone formation route, that is, formation of bone organ via a cartilaginous tissue step [ 8].
This is the first demonstration of a developmental role for any gene during post-embryonic stages of otic morphogenesis in the zebrafish.
The requirement for bmp2b function for correct morphogenesis of the semicircular ducts is the first demonstration of a developmental role for any gene during post-embryonic stages of otic morphogenesis in the zebrafish.
Our demonstration of the developmental neutrality of widespread mRFP1 expression paves the way for the incorporation of monomeric RFPs into mouse transgenic and gene targeting approaches [ 2].
Moreover, urinary concentrations of phthalate metabolites in pregnant mothers have been inversely correlated to anogenital distance among male infants, providing a demonstration of subtle developmental effects of prenatal exposure to phthalates in humans [ 8].
Nevertheless, the European Commission has banned BBP from toys and child care items at concentrations of greater than 0,1% by mass of the plasticized material [ 7] and new data is providing demonstration of possible developmental effects in humans [ 8].
In a study published in a previous issue of this journal by some authors participating in the current study, Swan et al. (2005) provided the first demonstration of subtle developmental effects, similar to those seen in animal studies, in human male infants exposed prenatally to phthalates.
By combining developmental genetics tools with tests of fitness in the field, this case study represents an example of a firm demonstration of how changes in developmental genetic pathways can be associated with the emergence of adaptive phenotypes in nature.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com