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After the demonstration of changes in cytoplasmic copper levels in P. anserina we asked whether this is specific for ageing in this fungal model system or whether such molecular changes are more general and conserved among organisms.
To our knowledge, this is the first demonstration of changes in both autophagic flux and aggregation of autophagy substrates in a vertebrate model of polyglutamine disease.
Because the three clusterin spots altered after Mtb-specific antigen stimulation were not clearly distinguished by immunoblotting, we did not attempt any further demonstration of changes in these signals in our study.
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The demonstration of change by irradiation has been documented for molecules such as collagen for over 50 years.
A more statistically robust test of mediation would require demonstration of change in MHSE prior to change in symptom and functional outcomes.
Our results provide a clear demonstration of change in the relative contributions of nociceptive neurons in a sensory network in diverse free-living nematode species.
In particular, the 25% reduction in local curvature of clonal boundaries separating FasIII-expressing from non-expressing regions represents both a readout for changed intercellular adhesion and a demonstration of how changes in adhesion can sculpt these clonally related cell populations.
The vote was a vivid demonstration of the changes wrought when Republicans regained control of the Senate in last fall's elections.
Variations in AI for each patient are shown in Figures 5 and 6. Figure 5 Demonstration of AI changes in group 1.
Figure 6 Demonstration of AI changes in group 2. Time 1, baseline; time 2, with wraparound; time 3, with twin block.
Variations in AHI for each patient are shown in Figures 3 and 4. Figure 3 Demonstration of AHI changes in group 1.
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