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This is the first demonstration of a specific self-association in solution for the Fis1 cytoplasmic domain.
Our demonstration of a specific interaction between anandamide and cholesterol has important consequences for the neurobiology of anandamide.
These data provide the first direct demonstration of a specific regulation of an important RNA helicase gene by HIF-1.
Clear demonstration of a specific learning effect necessarily requires experimental manipulation of the behaviour in question [26]; using experiments, teaching has now been demonstrated in widely divergent species (ants, meerkats, and pied babblers) [27] [30].
This is, to our knowledge, the first demonstration of a specific cellular role for this neural protein.
As a small demonstration of a specific research question for which our approach can be used, we investigated the plausibility of model simplifying approximations in kinetic modeling.
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It's also a bold demonstration of a more specific reality: In Africa art and science, including astronomy, have always intersected.
It's also a bold demonstration of a more specific reality: that in Africa, art and science, including astronomy, have always intersected, and continue to, whether in prayers on an ancient Egyptian mummy case asking that the deceased owner be lifted to the stars or in a contemporary video projection that simulates the aurora borealis.
23 24 Our demonstration of a genotype-specific effect actually provides, in itself, good evidence that CR3 ligation underlies the effects we observe.
As noted previously, some GPCRs have very low expression levels (e.g., <1000 receptor copies/cell) and ultimately the demonstration of a ligand-specific function is paramount.
Whereas previous reported effects produced by single-pulse occipital pole TMS are typically disruptive, here we report the first demonstration of a location-specific facilitatory effect on visual perception in humans.
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