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A post hoc assessment in high-risk patients allowed the demonstration of a significant risk reduction for nonvertebral fractures for both 3 and 5 years.
The demonstration of a significant impact of anemia on tumor response in internal radiotherapy should allow improvements by considering strategies under intensive development in EBRT [21 26] but, as of today, totally ignored in internal radiotherapy.
On the other hand, the demonstration of a significant difference between the TPOAbs URLs obtained with the five different automated IMA methods both in males and females, confirms the data of a previous study on the same topic, using indirect methods [15].
The first relevant result of this study was the demonstration of a significant difference between the TPOAbs URLs obtained with the five different automated IMA methods (both in males and females) and the results expected according to the corresponding package insert.
I think the most rewarding element of the Innovation Corps is when a principle investigator comes back and says, 'I'm now changing the way I think about crafting my research moving forward.' That feedback is an incredible demonstration of a significant change.
Primary Aim: Demonstration of a significant (≥ 20%) reduction in the serum levels of interleukin 6 (IL-6) 2.2.
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In this study, the downregulation of miR-34c in high grade serous carcinomas shown by microarray analysis was confirmed by qRT-PCR analysis but inter-method variability appears to have affected the reproducibility of demonstration of a statistically significant miR-34c prognostic association, indicating borderline prognostic significance, based on this cohort.
In regulatory settings, the criterion for substantial evidence of efficacy is frequently the demonstration of a statistically significant advantage over placebo in two or more studies.
This emphasises the fact that an analysis strategy employing interim analyses may or may not lead to early termination of the study: depending on the effect size and its variability, it may turn out that the originally planned total sample size is still required for demonstration of a statistically significant difference between different regimes.
On the basis of the demonstration of a statistically significant prolongation of overall survival, eribulin mesylate was approved by the US Food and Drug Administration FDAA).
In our study, the lack of demonstration of a statistically significant difference between omeprazole and rabeprazole for the main endpoint, i.e. 24-h percent time pH > 3, may be due to a second espece risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com