"If we can't change their minds," Mr. Blackwelder said, "we are still left with all the demonstration mechanisms that we used so effectively in Seattle".
The demonstration that mechanisms underlying weight loss in HD are related to disease onset would indicate that a more systemic, and possibly treatable, defect may be implicated early in the pathophysiology of HD.
Mechanical signals are a crucial regulator of stem cell behavior and important in tissue differentiation; however, there has been no demonstration of a mechanism whereby mechanics can affect gene regulation at the epigenetic level.
This is an important advance in stem cell mechanobiology as it is the first demonstration of a mechanism by which the mechanical micro-environment is able to induce epigenetic changes that control osteogenic cell fate, and that can be passed to daughter cells.
A demonstration following the mechanism is introduced in this paper for evaluating the integrated visualization approach.
As a demonstration, the formation mechanism of the ordered fibrous structure was analyzed, and polyvinyl alcohol (PVA) was processed into fibrous scaffolds.
In his 29 September memo, Moses says these improvements had led to alpha-particle heating that doubled the energy yield—"a clear demonstration of the mechanism that is needed to achieve ignition," he wrote.
The demonstration of a mechanism for injury of the zygapophysial joints complements postmortem studies that reveal lesions in these joints, and clinical studies that have demonstrated that zygapophysial joint pain is the single most common basis for chronic neck pain after injury.
Whilst differential expression of proteins in resistant and susceptible Rils suggests their involvement in the resistance mechanism, demonstration of their direct role requires much further experimentation.
This demonstration of a mechanism of invasion via a bridgehead has important implications both for invasion theory (i.e., a single evolutionary shift in the bridgehead population versus multiple changes in case of introduced populations becoming invasive independently) and for ongoing efforts to manage invasions by alien organisms (i.e., heightened vigilance against invasive bridgeheads).
