The findings are supported by the demonstration that in primary motor neurone cultures from VEGFδ/δ mice, axon outgrowth is significantly reduced compared to wild-type littermates.
Although correlation of IS with expression in T cell lines has provided some evidence of specific characteristics of the genomic regions that downregulate expression and favor latency and has provided tools such as latently infected cell lines such as J-LAT [ 59] that can be used in screening for LRA, a clear demonstration of similar associations in primary cells has been more difficult.
But as she took part in the demonstration, one primary school teacher in London said that while parents had at first been skeptical of the walkout, they had come around once they understood what was at stake.
We agree that our conclusions would be even further strengthened by a direct demonstration that DUX4 causes NMD inhibition in primary patient materials, in the absence of ectopic DUX4 expression.
Hypertension-associated CKD in African Ancestry populations has emerged as a highly relevant and well-suited opportunity for a 'prototype' genomic medicine demonstration project for common chronic illnesses managed in primary care settings.
Our demonstration of OSM-triggered phosphorylation of JAKs/STATs in primary rheumatoid synoviocytes suggests that these cells could be a source of activated STATs in rheumatoid synovial tissues [ 18].
On the whole, these data are the first demonstration of the presence of HERG channels in primary human neoplasias, and could candidate HERG as a potential tool capable of marking cancerous versus hyperplastic endometrial growth.
Direct demonstration of this is desirable to support its use in primary screening, The NorChip test had lower sensitivity but higher specificity, suggesting its role may be more in triage than primary screening.
In a recent report, Fostering Rapid Advances in Health Care Learningg from System Demonstrations, the IOM recommends that DHHS implement eight to ten ICT demonstrations (along with demonstrations in chronic care, primary care, state health insurance coverage, and state liability) to serve as building blocks for health system change.
The methods used to select patients for HER2-targeted therapy are based on immunohistochemical detection of HER2 over-expression and demonstration of HER2 gene amplification by fluorescence in situ hybridization (FISH) in primary tissue [ 12].
