Sentence examples for demonstration in mouse from inspiring English sources

The demonstration in mouse models that increased levels of these proteins correlated with increasing disease severity suggests that such a study is now warranted.

Notably, both events occur after initiation of high-level FOXN1 expression in the human thymus, consistent with the demonstration in mouse that thymic colonization with both mesenchymal and vascular endothelial cells is Foxn1 dependent.

But the ∼140 nm vertical axis of laminin must be reconciled with our definitive demonstration in mouse that there are two separate networks that meet in the middle of the GBM; the ∼200 nm wide mouse GBM cannot contain two fully extended laminin trimers, which would approach a 300 nm span.

We propose that the unique retinal sensitivity to tumorigenesis induced by RB1 loss is primarily due to a barrier to apoptosis inherent in developing retina, consistent with the demonstration in mice that the cell of retinoblastoma origin is intrinsically death resistant [ 31].

One of the most dramatic recent observations of the effect of FXR activation by secondary BAs was the demonstration in mice that the gut sterolbiome could control the size of the BA pool by removing the potent FXR antagonist tauro- β-muricholic acid.

Our data support this proposed elevated Wnt signalling in spondylitis with markedly decreased levels of the Wnt inhibitors DKK1 and SOST, the first such demonstration in a mouse model of SpA or AS.

The possibility of using autologous MSC for therapeutic application has become important following the demonstration in nonmyeloablated mice that allogeneic MSC are immunogenic and can be rejected [ 91, 92].

Therefore, they hopefully can be applied as autologous cells, which has become important following the demonstration in non-myeloablated mice that allogeneic MSCs are immunogenic and can be rejected [ 55].

Notable achievements are the first demonstration of localized gene editing in (mouse) epidermis and a pilot demonstration of localized efficacy of a therapeutic siRNA in a human who has a keratin mutation.

Hundreds of mouse models of human breast cancer have been developed since the first demonstration, in 1984, that the mouse mammary gland could be molecularly targeted and used to test the oncogenicity of candidate human genes.

Bit-tner's original demonstration of the 'milk factor' in mouse strains that had a high incidence of mammary tumors led to the discovery of the MMTV [ 10].