For example, how do you incentivize large companies to develop drugs that need to be used sparingly — through tax credits, efficacy payments upon demonstration of effective treatments or extending patent exclusivity?
Since the demonstration of effective cell sheet formation using temperature responsive substrates, a number of different stimuli have been utilized to facilitate cell sheet detachment.
While we believe that electrostatic preorganization is by far the most important catalytic factor, convincing the wider scientific community of this may require the demonstration of effective rational enzyme design.
A silver lining from the crisis was its demonstration of effective diplomacy, with negotiations led by the personal representatives of the Korean leaders: the South Korean national security adviser and vice chairman of North Korea's peak governing body.
Demonstration of effective and mechanism-driven rapalog-based combination regimens in patients should be a key effort in this direction.
But measurement of IFN-inducible gene expression should be valuable for selection of patients and demonstration of effective blockade of IFN in clinical trials targeting that pathway and might predict future flares in some patients.
Although broad in possible meaning, demonstration of effective citizenship and lifelong learning skills was defined here as combining information from multiple sources, collaborating on a variety of tasks, and applying knowledge to new contexts.
Baseline criteria included; demonstration of effective castration with circulating levels of testosterone at less than 1.7 nmol/L, previous treatment with docetaxel, and progressive disease (including increasing levels of PSA and radiographically confirmed progression).
Through the demonstration of effective social protection and inclusion municipal models, UNICEF in partnership with EU have been able to influence laws, policies and strategies at entity and state levels.
Similar molecular reactivities are supported by the demonstration of effective specific binding of thyroid hormones and chlorinated aromatic hydrocarbons with four different proteins, enzymes, or receptor preparations that are known or suspected to be involved in the expression of thyroid hormone activity.
