The demonstration that O&NS and multiple inflammatory mediators and proteases are elevated in exacerbations may account for the lack of clinical benefit seen with inhibition of single mediators 41, 42, 43, 44 and casts doubt on this as a valid therapeutic approach.
The present results confirm the recent demonstration in RA [ 45] and multiple sclerosis [ 46] that resident cells of target organs of autoimmunity could be induced to express BAFF under environmental conditions.
The proposed technique provides some advantages with respect to alternative approaches and is suitable for learning from both individual and multiple user demonstrations.
And we're also seeing a more in-depth demonstration of Tags, full-screen displays and multiple screens.
Third, the first probabilistic- (and performance-) based design methodology for US marine structures was drafted, and initial feasibility studies and demonstrations of multiple module dynamic positioning were completed.
The demonstrations, staged at a local Target and multiple Walmart stores, were brief and peaceful.
Our data show novel evidence for the existence of catecholaminergic cells in the extended amygdala of adult mice, and provide experimental demonstration for multiple embryonic origins of the TH-expressing telencephalic cells.
The demonstration of multiple competing independent clones and the identification of the origin of Barrett's oesophagus from the oesophageal gland squamous duct, structures present throughout the length of the oesophagus, allows the development of a new model of clonal evolution in Barrett's oesophagus.
This choice enabled the deployment of a demonstration to multiple locations, but was not always the most appropriate and will be augmented in future development to include integration with site-wide systems where appropriate.
To further reduce the effort in constructing task models, we have developed tools and techniques for automating the development and maintenance of these task models using fine-grained log of behavior demonstration by multiple experts (Kumar et al., 2014).
