Sentence examples for demonstrating the functional role from inspiring English sources
Silencing of Fas/CD95 by RNA interference, transfection with a FADD dominant-negative mutant that blocks Fas/CD95 signaling, and specific inhibition of caspase-8 prevented the apoptotic response triggered by edelfosine, hence demonstrating the functional role of DISC in drug-induced apoptosis.
Importantly, both Tip60 phosphorylation and p53 acetylation were blocked by treatment with the GSK3 inhibitor SB-21676, demonstrating the functional role of GSK3 in p53 activation.
Xenograft transplantation experiments using the MDA-MB-231 cell line have been instrumental in demonstrating the functional role of certain genes in organ-specific breast cancer metastasis.
This finding speaks for the need of a careful examination of the role of HLA for immune diseases, and also suggests identifying relevant HLA genes which can function either jointly or independently and demonstrating the functional role of HLA genes in recognizing virus-infected cells.
All reviewers found this work to be innovative and important, noting particularly the likely impact on the field of demonstrating the functional role of Let-7 regulation during carcinogenesis and liver repair and the potential negative effects of high dose Let-7 on normal liver function.
Although many studies have demonstrated the functional role of AdipoR1 in mediating metabolic effects of gAd [10], [43], the role of this receptor in mediating the anti-apoptotic effects of gAd in cardiomyocytes remained to be estabished.
The study presented here has identified six genes encoding putative AQP membrane transporters in Ae. aegypti and demonstrated the functional role of three of them in regulation of water transport.
Our observation that fibrin formation was abrogated in the presence of supraphysiological concentrations of annexin A5 [28], [28], demonstrates the functional role of coagulation factor interactions with exposed PS during thrombus formation.
Many other studies in different woody plant species have demonstrated the functional role of hydrolysable and condensed tannins as plant defences against generalist insects [ 46].
