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Regardless, genetic deletion of Puma, a pro-apoptotic Bcl-2 family protein under p53 control, is strongly protective in both models, demonstrating that the models are capable of detecting functional contributions of p53-regulated pro-apoptotic genes to neuronal death.
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Validation requires demonstrating that the model is accurate in the population of individuals for whom it is intended.
After demonstrating that the model process is WSS, an appropriate method of simulation is introduced based upon the WSS property.
Four application examples demonstrate that the models are easy-to-use design tools for structural engineers.
The results demonstrated that the models so developed for seismic hazard estimation did not necessarily reproduce the observed seismicity.
This paper demonstrates that the models and equations developed for 2D can be extended to three-dimensional (3D) cases.
Tables 4, 5, and 6 demonstrate that the models successfully extracted key lignin and lignin model compound vibrational modes.
MCA demonstrates that the models are very sensitive to the protein synthesis rates and to protein turnover rates.
The scatterplots reflect the strength of each of the developed models and demonstrate that the models fit the observations well with no significant outliers.
Although model parameter values can be fine-tuned so that model behavior matches clinical data, it may not be possible to demonstrate that the models are physiologically realistic.
Previous work demonstrated that the models were suitable for clinical use, and that overly optimistic or pessimistic estimates generated by PATHFx were of unequal clinical significance [ 14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com