Sentence examples for demonstrating target from inspiring English sources

After a 48-hour incubation with tremelimumab in vitro the intracellular expression of CTLA4 in monocytes decreased, demonstrating target modulation even with undetectable surface expression of CTLA4 (Figure 3).

Expression of the Bclx protein, which shares significant sequence homology with Bcl-2, was not affected, demonstrating target specificity of the G3139 oligonucleotide.

Given the studies in mouse models and dogs with MCT demonstrating target inhibition at toceranib plasma concentrations at or above 40 ng/ml [ 2, 4] dosing of toceranib at 2.4-2.9 2.4-2.9esults in plasmg/kgncentresults of drug linely to effectively inhibit target receplasmayrosine kinases in vivo.

The SAIL-specific ADCs exhibited potent in vitro cytotoxic activity against the sarcoma cell line expressing high levels of SAIL, but had no effect on the nontransfected parental sarcoma line, demonstrating target-specific cytotoxicity.

Figure 1 represents a typical case demonstrating targeting volume.

Here, we take the next step: demonstrating targeted delivery into tumor cells in vivo.

Moreover, globular fluorescent structures were highly abundant in low-density fractions (Fig. 5C), demonstrating targeting of the recombinant protein to plastoglobules.

However, to our knowledge, there has been no report clearly demonstrating targeted relaxation of selective pressures in such functionally redundant genes leading to neutralization.

"They have shown their competence through demonstrated target practice.

These nanoparticles demonstrated target specific delivery in human lung cancer cells (which overexpress CD44 receptors).

The compound was used to demonstrate target engagement and inhibition of Cat K in an in vivo dog PD model.