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This result is consistent with clinical findings demonstrating skin thinning as a long-term treatment effect.
At diagnosis, the right breast mammogram showed linear and pleomorphic micro-calcifications in a segmental distribution over the lower-central and entire lower-inner gradient while also demonstrating skin thickening in overlying zones.
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In advanced disease, the involved breast can be significantly enlarged and demonstrate skin retraction in more than one quadrant.
Pathologic examination demonstrated skin covered parasitic body.
This increase in DEC-205 expression upon activation of skin DC has previously been demonstrated in skin explant culture 11.
Allergy-related nasal symptoms were significantly reduced in the vaccinated group, and the environmental challenge study also showed that BM32 reduced skin reactivity to grass pollen as demonstrated by skin prick testing.
We are not aware of published data directly confirming isocyanate skin absorption in humans; however, a number of studies indirectly demonstrate isocyanate skin absorption.
Consistent with the in vitro data, we also have demonstrated that skin biopsies from patients with SSc as well as the bleomycin-induced skin fibrosis model both have TLR3 expression that localizes to fibroblast-like cells.
In parallel, a series of mouse models have demonstrated that skin homing TEM are generated from naïve T cells after antigen encounter in lymph nodes draining skin, and these TEM rapidly migrate to and extravasate in skin [8].
We demonstrate that skin pigmentation is highly heritable, but known pigmentation loci explain only a small fraction of the variance.
Existing comparisons derived from surface wound mapping are limited in that they can only demonstrate the skin entry wound location.
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