Exact(3)
The structure of the most active triple mutant (L107G/L108D/F222H) enzyme was determined by X-ray crystallography demonstrating significant changes in the topography of the active site facilitating productive binding of Aza as a substrate.
The microarray results were validated via real time-PCR for 9 genes, representing approximately 10% of the genes selected based on their potential interest from the larger pool of genes demonstrating significant changes in expression in the microarray analysis (95/389).
However, four of the five cell lines that did not demonstrate significant changes in the degree of Erk1/2 phosphorylation in response to VPA did not have IC50 values for growth within the tested concentration range (below 3 mM; Table 1), whereas all five cell lines demonstrating significant changes in the degree of Erk1/2 phosphorylation in response to VPA had IC50 values for growth below 3 mM.
Similar(57)
Previous studies have demonstrated significant changes in red blood cell (RBC) transfusion practice over several decades.
Coatings obtained with the Nd YAG source demonstrate significant changes in the matrix microstructure with WC/W2C particle addition.
Our data demonstrate significant changes in Muc and TFF mRNA expression in pediatric patients with IBD suggesting a role in mucosal healing.
TEM analysis demonstrated significant changes in the morphology as well as in the microstructure of these NWs, revealing a certain radiation-susceptible nature.
For example, CdSe NPs placed in polymer matrix demonstrate significant changes in their temperature-dependent PL intensity and maximum PL spectral shifts.
Results demonstrated significant changes in performance of spinal manipulation by students using the training aid instrument versus those who did not.
Conclusions: Both treatment groups demonstrated significant changes in visual function and perimacular hemodynamics, sustained after the terminal 3-week washout period.
As predicted in the hypotheses, these results demonstrated significant changes in heart rate in response to completion of verbal fluency measure based on anger expression style (Figs. 3, 4).
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