We demonstrate profoundly different biological effects in vitro and in vivo of the prodrugs compared to parental VP-16.
This much is frequently emphasized when people discuss the Milgram experiment, and its extraordinary fact about human beings that Milgram was prompted to investigate because, of course, this possibility had just been demonstrated profoundly for the world outside of the laboratory.
By contrast, peritoneal macrophages obtained from MyD88−/− mice and TLR2−/− mice demonstrated profoundly impaired TNF, IL-6 and MCP-1 secretion in response to LVS infection compared to macrophages from B6 mice.
Previously, we have demonstrated profoundly hypoxic synovial environment of the inflamed joint (approximately 3%) [ 26].
In addition, several patients with sJRA who demonstrated profoundly depressed NK cell cytolytic activity were receiving only non-steroidal anti-inflammatory drugs.
Social science has amassed substantial evidence demonstrating how profoundly we are shaped by subtle cues, motivators, and enablers.
In particular, Bishop locates Jung in a philosophical and literary context, demonstrating "how deeply and profoundly Jung belongs to a broader stream of thought in German culture".
Then Verdi tweaks it with a dotted rhythm — slightly militaristic, slightly breathless, slightly curt — that demonstrates how profoundly the character is lying to himself.
With the nanoparticle and PEG brush heights on the same lengthscale, variations in ionic strength are demonstrated to profoundly influence the capture of S. aureus on these surfaces.
"In Memoriam" demonstrates how profoundly television, video, cell phones -- the entire new world of technology -- have shaped our experience and memories of the attacks and the new global war they are part of.
