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Using these models, I evaluate the relative contribution of mutator mechanisms to tumorigenesis, considering in a quantitative fashion those issues which have historically been raised as counterarguments to the mutator hypothesis, and demonstrating predominance of mutator pathways in most instances.
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The failure pattern demonstrated predominance of cohesive failure within resin cement for all silanes tested regardless of the heating treatment.
DNA fingerprinting has demonstrated predominance of the Beijing genotype among Mycobacterium tuberculosis strains isolated in Southeast Asia.
The peripheral blood smear demonstrated predominance of macrocytic cells with no hemolytic findings such as fragments or spherocytes.
The demonstrated predominance of viruses among medically attended AGE cases should help prevent the unnecessary use of antimicrobial drugs and spur development of novel interventions specific for the unique transmission pathways of viruses.
Previous heart rate variability (HRV) studies in asthmatic subjects (AS) demonstrate predominance of parasympathetic drive concomitant with low HRV, which is against the general belief that enhanced parasympathetic modulation improves HRV.
In addition, all four study groups described here were quite homogeneous in terms of self-reported skin color (a feature used as proxy for 'race' or ancestry background in Brazil) corroborating with previous population-based studies that demonstrate predominance of European genomes in this specific region.
c CAM5.2-red immunostain is completely negative, confirming the absence of RPE (magnification, ×200) Fig. 3 Immunohistochemical staining of the ERM from case 1, demonstrating a predominance of lymphocytes among the inflammatory cell population, and out of the lymphocyte population, a predominance of T cells over B cells. a CD45-red immunostain highlights lymphocytes (magnification, ×100).
Of the 112 total effects clustered in the mouse, 28 of these were liver toxicities, demonstrating the predominance of the liver as a target organ in the mouse.
Blocking the GrB but not the CD95 cytolytic pathway almost completely abrogated NK cytolytic potential, demonstrating the predominance of the granzymeB pathway in NK cell mediated lysis of parental as well as CDDP-resistant variants of osteosarcoma cells (Fig. 4c).
These studies are consistent with a possible role of oxidative damage in driving mutational biases, demonstrating a predominance of both C G > T A transition (all studies) and C G > A T transversion (all but Arabidopsis).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com