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Earl W. Sutherland, Jr., in full Earl Wilbur Sutherland, Jr. (born Nov. 19, 1915, Burlingame, Kan., U.S. died March 9 , 1974 Miami, Fla ., American pharmacologist and physiologist who was awarded the 1971 Nobel Prize for Physiology or Medicine for isolating cyclic adenosine monophosphate (cyclic AMP) and demonstrating its involvement in numerous metabolic processes that occur in animals.
Consistently, WUS is a direct activator of the floral patterning gene AGAMOUS [25], demonstrating its involvement in both proliferation and differentiation.
Leptin also regulates the excitability of inter alia hippocampal neurons as well as synaptic plasticity, 49 demonstrating its involvement in neuroendocrine functions.
In addition, ITIH5 has been proven to be a novel prognostic marker in invasive node-negative breast cancer, demonstrating its involvement in tumor progression, invasion, and metastasis[ 37].
The fact that insulin is biologically relevant for skin cells derives from the observation that insulin is an essential component for cultured human keratinocytes, demonstrating its involvement in the regulation of proliferation, survival, and metabolism [ 114].
In mice, ANGPTL4/ FIAF is increased in the plasma by fasting and decreased by high fat diet [ 39], demonstrating its involvement in lipid capture in difficult physiological conditions, of which PE may represent a paradigmatic case.
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Although the hippocampus is not commonly thought to be involved in addictive behaviors, recent evidence demonstrates its involvement in psychostimulant responses and addiction.
rufipes, the determination of the role of this species in malaria transmission needs further investigation to incriminate it, as a recent study conducted in Burkina Faso has demonstrated its involvement in the transmission of human Plasmodium [ 30].
VEGFR1 was previously thought to be a non-signaling "decoy" receptor, but recent studies have demonstrated its involvement in pathologic angiogenesis [7] and the recruitment of BMDCs [8], including macrophages and endothelial precursor cells [9].
Titration of hK1 demonstrated its involvement in GIST invasive behaviour, but not proliferation.
Evidence obtained from deletion analysis of the analogous yeast complex (XRM) demonstrated its involvement in S-phase control in response to replication stalling and DSB.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com