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The effects of orexins on sleep architecture have been extensively studied in tethered models demonstrating increased levels of wakefulness.
This is the first report demonstrating increased levels of L-PGDS in OA cartilage.
This study confirmed findings demonstrating increased levels of lipid peroxidation in vitro observed in autopsy samples of brains afflicted by AD [ 10].
Directly, by demonstrating increased levels of dnTCF1 transcript, and indirectly, by demonstrating downregulation of c-Myc, a well-known target of the inhibited β-catenin/TCF complex (Supplementary Figure 3).
Previous studies have supported this concept, demonstrating increased levels of Bacteroides and Firmicutes bacteria in the ilea of Nod2 −/− mice relative to WT controls, 32 as well as global alterations of Nod2 −/− gut microbial communities analysed by high-throughput pyrosequencing.
8 35 36 The observed enhanced expression of COX-1 and COX-2 in muscle tissue from patients with myositis is in accordance with previously published data demonstrating increased levels of COX-1 and COX-2 mRNA in inflammatory cells and vessels in muscle tissue from patients with myositis.
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A self-administered questionnaire was designed around a set of six clinical planning scenarios demonstrating increasing levels of difficulty.
This is reflected by successive thresholds (point at which probability of being in adjacent thresholds is equal) demonstrating increasing levels of the construct being measured.
Transformed cells demonstrate increased levels of glycolysis, which are associated with increased levels of glycolytic enzyme mRNA and protein [59].
The mean spectra obtained from selected regions demonstrate increased levels of glycogen in the squamous area compared with increased DNA levels in the abnormal region.
PEG LN gels demonstrated increased levels of the osteogenic transcription factor osterix relative to day 0 levels.
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