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The I424S and A427D mutants exert differing effects on SQSTM1 function relative to other PDB mutants, demonstrating diverse molecular mechanisms operating in the aetiology of PDB.
There are a number of findings demonstrating diverse transcriptional regulation of E2f-responsive genes, suggesting that expression of these genes is regulated by different sets of Rb-E2f protein complexes [ 16].
A proteomic comparison of bovine aortic ECs, lymphatic ECs and venous ECs by MALDI-TOF identified numerous variably expressed proteins [ 17], again demonstrating diverse expression patterns of ECs from different vascular beds.
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This experience convincingly demonstrates diverse advantages of applying fuzzy mathematics in optimization and decision making problems of power engineering.
As Scott Page, a professor of complex systems, has demonstrated, diverse groups have greater potential to generate effective and innovative solutions to tough problems.
HDAC inhibitors (HDACi) such as sodium butyrate and trichostatin A demonstrate diverse biological effects which have led to broad speculation about their therapeutic potential in multiple disease states.
Studies have demonstrated diverse genetic alterations in osteosarcoma cells including structural abnormalities, gain and/or loss of chromosomes, mutations in tumor suppressor genes and epigenetic modifications (Kansara and Thomas, 2007; Broadhead et al., 2011).
MSCs have also been shown to have immuno-modulatory properties that, dependant on the MSC source and treatment context, may demonstrate diverse effects from aiding tissue repair[18] to promoting tumour formation[19].
A better understanding of tuberculosis lesion pathogenesis is emerging from evaluating animal models that demonstrate diverse in vivo responses to experimental infections.
These three sizes of nanoparticles demonstrate diverse thermodynamic stabilities.
Estrogen demonstrates diverse effects in humans and has a critical role in breast cancer development.
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