Our results support previous studies demonstrating a role for LRR1 in plant immunity.
These QTLs often affect local chromatin and transcription but can also influence long-range chromosomal contacts, demonstrating a role for natural genetic variation in chromosomal architecture.
In a recent study, Hugo et al. use multidimensional analysis of the dynamic genetic, transcriptional, epigenetic, and immune landscape alterations in baseline and MAPK inhibitor-resistant melanoma tumors, demonstrating a role for 'non-genomic' drivers in cancer evolution.
Lastly, J774.A1 murine macrophages co-cultured with transfected SK-LU-1 cells showed a 14- to 35-fold increase in the iNOS-Arg-1 ratio, supportive of previous results demonstrating a role of miR-125b in macrophage repolarization.
Along this line, transfection of MN9D cells with specific Sim1 siRNA significantly downregulated Gata2 expression (Fig. 7A), demonstrating a role of Sim1 in maintenance of Gata2 expression.
These results are consistent with prior findings demonstrating a role for misfolded huntingtin in eliciting mitochondrial dysfunction and oxidative stress [49], [50].
Previous studies with the homologous gp130 molecule of the IL-6R demonstrating a role for the STQPLL motif in receptor internalization utilized a fibroblast model [20], [23].
These cell types exist prior to the earliest formation of the CNS, clearly demonstrating a role for GABA signaling in a completely non-neuronal context.
Thus, in vitro data from other model systems demonstrating a role for Nod2 has been consistent with prior observations with B. burgdorferi [17], [25], [55] [57].
We observed vascular malformations and hemorrhage during embryonic development of mice homozygous for a mutation inactivating ADAM17, thus demonstrating a role for this protease in modulating vascular development.
To the best of our knowledge, there are no previous reports demonstrating a role of this protein in cytokine-mediated apoptosis.
