However, only 7 of these studies demonstrated a favourable effect on patient outcomes in addition to a positive effect on processes of care.
Several studies have demonstrated a favourable effect of bed rest for women with a triplet pregnancy on fetal growth [ 2, 3].
10 12 The use of topiramate, a kind of AED, at a daily dose of 50 mg demonstrated a favourable effect in reducing the migraine days.
We did not demonstrate a favourable effect of haemofiltration on multi-organ failure or capillary leakage, expressed as better renal function, lower vasopressor score or less need for fluid resuscitation.
Meta-analyses of lifestyle interventions demonstrated a favourable effect on BMI Z-score at 6 months [mean difference (MD) = -0.06 (95 % CI -0.12,–0.01)] in children aged less than 12 years, and in those over 12 years of age [MD-0.14 (95%% CI-0.17,–0.12)].
Recent findings reported by our group [ 19] confirmed these data and demonstrated that celecoxib had a favourable effect on proteoglycan synthesis, retention, release and content in both degenerated (preclinical) and (late-stage) OA cartilage.
In the present study, insulin detemir also demonstrated a favourable weight-sparing effect, and was associated with higher odds (1.75-fold) of weight loss ≥1 kg compared with patients in the insulin glargine group.
Although it is possible that a lower dosage of corticosteroids could obtain a similar effect, we believe that the use of a higher dose may be justified until a favourable effect has been demonstrated.
