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Dose dependent studies indicated that SVOP demonstrates the highest affinity for NAD, in contrast to SV2, which binds both NAD and ATP with equal affinity.
And whereas SVOP demonstrates the highest affinity for NAD (IC50∼0.25 mM versus ∼0.75 mM for ATP), SV2 shows an equal affinity for both NAD and ATP (∼0.4 mM for both).
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Studies evaluating binding of trastuzumab to effector cells demonstrated the highest affinity of FcγRIIIA in primary NK and NK-92 (V-158) cells.
Found on GPIbα [30], the sLacNac trisaccharide was present in nineteen of the twenty SSL5-binding glycans that demonstrated the highest affinity in binding.
The molecules which demonstrate the highest affinity constitute interesting candidates for the development of novel antibacterials which could potentially interfere with Yersinia's immune system subversion mechanism.
UGT1A7 demonstrated the highest affinity for NI-12a (Km = 62 μM), and UGT1A10 had the lowest affinity for NI-12a (Km = 500 μM).
Although other sequences were also tested, this one demonstrated the highest affinity to various colon cancer cell lines, e.g., HT-29, SW-480, etc.
The electrochemical behavior of the polymeric films was systematically investigated using differential pulse voltammetry (DPV) to demonstrate the high affinity of the biohybrid interfaces for Cu II) ions.
The phage ELISA assay demonstrated the high affinity binding of bifunctional bacteriophages to NMP22 antigen at concentrations of 105 and 106 pfu/ml.
Our results demonstrate the high affinity that GO has for binding a wide range of aqueous metals, and the results can be used to estimate with a reasonable degree of certainty the distribution of metals in complex GO-bearing environmental or engineered systems.
These dramatic spectral changes indicate that the binding of Zn2+ induces conformational changes, demonstrating the high affinity of the apoprotein toward Zn, consistent with the ITC results described above.
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CEO of Professional Science Editing for Scientists @ prosciediting.com