Early studies of SGAs demonstrated superiority over the FGAs, including a lower incidence of EPS, superior efficacy for positive, negative and mood symptoms, improved tolerability, as well as cognitive enhancing effects [ 5- 8].
The combination of aspirin and extended-release dipyridamole has demonstrated superiority over aspirin in two large secondary stroke prevention trials.
The trial was ended early because the combination drug, which included sacubitril (an experimental drug) and valsartan (a current therapy), demonstrated superiority over enalapril (another current therapy).
"It's such an old story trope: A white person demonstrating superiority over Asians".
A Phase 3 clinical trial of 3,4-diaminopyridine phosphate to treat LEMS demonstrated superiority over placebo in both co-primary endpoints of the trial.
Furthermore, several recent clinical trials with medications which are effective in polyneuropathy and postherpetic neuralgia have failed to demonstrate superiority over placebo in painful radiculopathy [2], [3], [4].
In these cases, DES development based on traditional preclinical, animal and human testing has not identified devices that demonstrate superiority over non-DES controls.
Denosumab demonstrated superiority over zoledronic acid in preventing SRE in three large, randomized, controlled trials 32– 32.
The FDA also requires combination treatments to demonstrate superiority over each individual component before Phase III.
However, demonstrating superiority over standard of care in RCTs has often been unsuccessful in LN.
The authors demonstrated the potential of robotic needle guidance to improve needle interventions, demonstrating superiority over a commercial navigation system.
